Four Basic Requirements for Leaving Antivirus Behind
Traditional endpoint antivirus, which relies on static signatures to identify malicious files, URLs and IP addresses has outlived its useful life. New attack techniques, including polymorphic malware, packers and wrappers — can make a known binary appear completely new and therefore undetectable by antivirus.
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Story added 21. December 2015, content source with full text you can find at link above.