Gene therapy advance thwarts brain cancer in rats

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering have designed a nanoparticle transport system for gene delivery that destroys deadly brain gliomas in a rat model, significantly extending the lives of the treated animals. The nanoparticles are filled with genes for an enzyme that converts a prodrug called ganciclovir into a potent destroyer of the glioma cells.